Alcohol converts sugar to ketones by acting upon the enzyme hexokinase, which is found in sufficient amount in the liver. This gives rise to a chain of reactions:
Beta oxidation of the alcohol by aldehyde dehydrogenase results in its dehydration to acetaldehyde. Two molecules of NAD+ are reduced and one molecule of GTP is produced in this reaction.
Acetaldehyde is converted to acetate by the enzyme alcohol dehydrogenase. The overall reaction for this step is:
Acetate is split into two molecules of acetyl CoA by the enzyme acetyl-CoA synthase. This step also requires one molecule of FAD, and produces 2 molecules of NADH.
The acetyl CoA molecules are oxidized to carbon dioxide by the enzyme complex pyruvate dehydrogenase. Two moles of NAD+ and 2 moles of FADH2 are reduced in this reaction.
The acetyl CoA molecules are converted to acetoacetate by the enzyme thiolase.
No comments:
Post a Comment